SpyderTracks
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That should be a really good motherboard as all the USB ports run directly from the main chipset rather than an individual usb controller, so should be good there.let me just research the usb controllers on the motherboard you selected.
I can find no reference to requiring a scratch drive, but, for optimal IO throughput, it is suggested to have 1 main OS drive and for the program, then a separate drive for samples and VST's, and a third for your project files.
That's in totally utmost high end perfection, I don't think by any means it's a requirements, although I would suggest having a primary OS/program/samples & VST's and then projects on a separate data drive (standard SATA SSD would suffice).